Nostradamus: The Last Prophecy transports players to 16th century Provence, in a country ravaged by religious wars and devastated by the plague. Despite the end of her rule as regent three years ago, Catherine de Médicis still holds the reins of power, making her the target of repeated attacks by the French nobility. In March 1566, upon falling victim to a terrible curse, she turns to her doctor and astrologer, Michel de Nostre-Dame, better known as Nostradamus.
Too old and weak to take on such a mission alone, the famous prophet sends his daughter Madeleine to serve the Queen in her hour of need. However, as there are no female astrologers or doctors in medieval times, Madeleine must disguise herself, assuming the identity of her younger brother, César.
Alternating between Madeleine as herself and Madeleine disguised as César, players are plunged into a thriller where political scheming and ancestral prophecies are intertwined.