Sometimes a game needs a specific DirectX file and won't run without it, even if you have a newer version of DirectX installed. Rather than reinstalling the game, you could try running the DirectX setup that came with it.
For my Gray Matter install it's in My Documents\Gray Matter\Support\directX. (I can't remember if I chose to install to My Documents or if it went there automatically, but it should be easy enough to find.) There's a file in this folder called DXSETUP.exe that can be launched independently from the game's installer.
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