The last time I really got frustrated was with the slider puzzle in Art of Murder: Hunt for the Puppeteer. It's stupendous how much I hate anything that relates to the slider puzzle.
But beyond that, I usually stay cool with most puzzles I encounter. I take my time and try different ways to approach obstacles. When all else fails, I peruse MaGtRo's most excellent walkthroughs to get unstuck. She's simply amazing.
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