The only one that annoyed me was Sinking Island. Even in adventure mode you are on some sort of clock so certain things still happen right in the midle of conversations. Luckily the game tells you exactly where the character you were talking to went.
As for giving up? It takes alot before I finally state that I can't figure something out. I usually try to use everything and take alot of notes especially if I find a code or document that I can't take with me. I also have alot of patience. I tend to look at everything I can and pick up anything not nailed down. If I can't pick it up right then, I write down where it is for later. If I get stuck on a puzzle I usually take a break, step back, and try to think outside the box (sometimes way outside the box).
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