Well if you're after an adventure game to 'sink your teeth into' then a perfect suggestion is Dracula: Origin.  Still haven't played it myself... yet. It's modern (hasn't been out long), pure point 'n click and should work on Vista.
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Now Playing: Broken Sword: Shadow of the Templars - The Director's Cut (DS and iPhone), DOOM 3: Resurrection of Evil, Hotel Dusk: Room 215, Phoenix Wright: Ace Attorney Justice for All, Silent Hill - HD Collection
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