Mechanical puzzles are my weaknesses, can't think of anything else. For example a simple slider puzzle on Still Life is beating the crap out of me.
I guess the main problem with them I have is: A - I'm not smart enough for them
B - They don't interest me, and I have hard time to focus on things that doesn't interest me.
Someone mentioned pixel hunting... I've made a habit to hunt properly every area I hit for starters so I wouldn't miss anything, so I guess I'm pretty good at it.