Go for it.
I know Neverhood and Grim Fandango are possible to run... but might require some poking.
And I have not managed to get a single node-based panoramic view type game to work.
And I will try Bone and Sam&Max shortly... but last time I tried Out From Boneville, the 3D models had weird spikes sticking out of them. Fone Bone looked like something out of Spawn.