Yes - we differentiated it in many ways.
Most obviously is the switch to a 3D engine, which allowed a more free flowing experience in the environments, characters, and evidence.
We also added cool cinematography techniques to make the experience more like the show. So there are more TV-like cuts, and a cinematic experience.
Thirdly we added a lot of extra CSI teamwork - so in the new games you can mull over the case with Catherine and Warrick, for example....
There's a detailed blog of even more changes we made on the Telltale site.
You can view it
here.
-greg