Lost in Time...
 

In my opinion, Lost in Time had the best puzzles I have seen in an adventure game. Where they all perfect? No. But the style of puzzle and the focus on puzzles over conversation was a strong point. The game is cheesy as hell, but its the closest to Magyver a game (for me) has ever gotten.

What game do you think is most similar to Lost in Time?

I have a soft spot for the Coktel Vision games. On a side note, the game is now supported in the subversion of ScummVM. DrMcCoy is doing great work with these games. Next is Woodruff.