I second Discworld 2 (haven't played the first one) and I would also add Toonstruck. It's difficult to get a hold of it these days and possibly a bitch to get it running on today's hardware/OS but totally worth it.
I also have a very soft spot for Edna & Harvey: The Breakout and I think the simplistic art style and whacky situations will be appealing to you. Be advised, though, that compared to most of these games, Edna & Harvey is a bit on the "wordy" side and as a result its humour is a mixed bag. Most of the time I thought the jokes worked but sometimes it just tries too hard with the dialogue and comments and the constant blathering wears the whole experience down a bit.
I guess it's quite obvious but have you tried Grim Fandango (also by Tim Schaffer)? It's more "intellectual" and less slapstick than those games but so incredibly witty, charming and uncanny that you will fall in love with it right away, if you don't mind the keyboard-driven controls.
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