Oh yes, I remember those things quite clearly in Runaway games. For example in The Dream of the Turtle I remember I accidentaly used a glass shard on that drunk lemur in Brian's inventory, and Brian said something like
"I don't wanna kill the poor guy" I thought it was pretty funny as well as some other lines I don't remember.
Also I remember in Monkey Island how Guybrush would sometimes say something funny and then turn himself towards me like he's talking to
me e.g.
“That’s the second biggest monkey head I’ve ever seen!”
So yeah, the main character adressing me, never really annoyed me, neither did I thought it was weird or unnatural, because I found it to be quite funny and amusing.
