Yes, mostly inventory, combining items and using an item on something...
Some more lengthy dialog of sort are plenty in Simon games.
You can't be serious?!
Stop clutching at straws!
Maybe you should change you're medication, because I don't see how that's gonna work!
Why don't you use it on yourself ?!
...referring to the actual player...
I also remember a game where the character knocks on your screen monitor and tells you something... but I can't remember where...
Mostly I don't mind,and they're funny, only a few exception I found... let's say annoying...