Would love to see (or rather, hear) that too, Lee - he's got such a charming and characteristic voice, I watched the Stuart Little movies just because of him
! But he hasn't been acting for five years, not even voice work. And looking at
this 2010 clip I doubt he would be able to carry a leading role over several episodes. Would be nice with just a small cameo from him if they decide to make Doc the main character.
I do hope they get Christopher Lloyd and Thomas F. Wilson, though. They both did video games before so it's not all that unlikely.
Edit: And because the other video clip made me sad,
here's a blooper from The Frighters.