Crank
Jason Stratham is a hitman who wakes up to find he's been injected with a chinese synthetic poison that will kill him if his heart rate isn't racing.
Roll on a full on action flick where he's out to get the people who killed him, but to stay alive he has to keep his adrenaline levels up.
It's completely stupid, no plot movie with outrageous action "Speed" without a bus. Jason Stratham is perfect as the hitman wisecracking arse kicking hero.
The camera work can be annoying, but it's one hell of a fun ride.
http://www.apple.com/trailers/lions_gate/crank/